Australia were dismissed for 99 by South Africa on day four of the second Test in Gqeberha. The hosts were forced to follow-on for the third time in 38 years.
South Africa reached 425-9 declared after Temba Bavuma scored 179 runs. Marco Jansen took 5-33 to lead the bowling attack, while Kagiso Rabada and Wiaan Mulder each claimed two wickets.
The visitors trail by 422 runs and hold a 326-run first-innings deficit. Steve Smith managed 28 runs, but no other Australian batter passed 14.
The highest partnership during the collapse was 23. Marco Jansen nicked off Scott Boland with his first ball of the day and pinned Travis Head lbw for 14.
Marnus Labuschagne was caught at slip for 14, while Anrich Nortje bowled 3.3 overs. Jansen achieved his fifth Test five-wicket haul in the performance.
Australia were previously forced to follow-on against India at Sydney in 2019 and at Trent Bridge in 2005. The team also conceded a first-innings deficit against West Indies in November 1984.
South Africa have more than 150 overs to complete victory.
