Ann Hornaday died at her home in Baltimore at the age of 66 after fighting glioblastoma. Born on 9 March 1960 in Iowa City, Hornaday was adopted by Mary Mills and William R. Hornaday Jr.

She grew up in Des Moines and later graduated from Smith College in 1982 with a major in government. Hornaday's professional career included roles as a freelance writer in New York and a film critic for The Washington Post.

Her portfolio also featured contributions to The New York Times and a two-year tenure at Ms. Magazine. The critic also served as the film reviewer for the Baltimore Sun and the Austin American-Statesman.

In addition to her journalism, she worked as the personal assistant to Gloria Steinem. She was married to Dennis Greenia for 26 years and had a daughter, Victoria Greenia, and a stepdaughter, Leila Greenia.

Hornaday was also a parishioner and Sunday school teacher in Baltimore and had a brother named William Hornaday III.